Current Desensitizing Agents for the Treatment of Dentin Hypersensitivity




dentin hypersensitivity, treatment, dentin desensitizing agents


Dentine sensitivity is a common condition characterized by short-term, sharp pain triggered by thermal, tactile, and chemical stimuli. It ranges from mild and sudden discomfort to more severe cases that can significantly impact the quality of life. Various treatment approaches have been developed to manage dentine sensitivity. The initial step typically involves desensitizing agents like desensitizing toothpastes and mouthwashes that patients can apply at home. Following this, professional treatments are administered, which may involve either invasive or noninvasive procedures in a clinical setting. Noninvasive clinical treatments often refer the application of desensitizing agents. This study aims to explore the current desensitizing agents utilized in treating dentine sensitivity.


Admira Protect – Voco Dental Brochure (

Arrais, C. A. G., Chan, D. C. N. ve Giannini, M. (2004). Effects of desensitizing agents on dentinal tubule occlusion. Journal of Applied Oral Science, 12(2). doi:10.1590/s1678-77572004000200012

Bekes, K., Schmelz, M., Schaller, H.-G. ve Gernhardt, C. R. (2009). The influence of application of different desensitisers on root dentine demineralisation in situ. International dental journal, 59(3). doi:10.1922/IDJ-2095Bekes06

Brännström, M. ve Åström, A. (1964). A Study on the Mechanism of Pain Elicited from the Dentin. Journal of Dental Research, 43(4). doi:10.1177/00220345640430041601

Canali, G. D., Rached, R. N., Mazur, R. F. ve Souza, E. M. (2017). Effect of erosion/abrasion challenge on the dentin tubule occlusion using different desensitizing agents. Brazilian Dental Journal, 28(2). doi:10.1590/0103-6440201700811

Chow, L. C. (2009). Next generation calcium phosphate-based biomaterials. Dental Materials Journal. doi:10.4012/dmj.28.1

Clinpro White Varnish Terchnical Product Profile (

Clinpro Xt Varnish Brochure (

Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. (2003).Journal (Canadian Dental Association) içinde (C. 69).

Cummins, D. (2010). Recent advances in dentin hypersensitivity: Clinically proven treatments for instant and lasting sensitivity relief. American Journal of Dentistry.

Dall’Orologio, G. D., Lone, A. ve Finger, W. J. (2002). Clinical evaluation of the role of glutardialdehyde in a one-bottle adhesive. American Journal of Dentistry, 15(5).

Dixit, A., Awasthi, N., Ahirwar, A., Nanu, T., Nathan, K. B. ve Jose, J. A. (2021). Impact of Various Desensitizing Agents on Occlusion of Dentinal Tubules: A Scanning Electron Microscopic Study. Journal of Contemporary Dental Practice, 22(7). doi:10.5005/jp-journals-10024-3129

Escalante-Otárola, W. G., Castro-Núñez, G. M., Leandrim, T. P., Alencar, C. M., de Albuquerque Jassé, F. F. ve Kuga, M. C. (2021). Effects of Remineralizing Agents Based on Calcium Phosphate, Sodium Phosphate, or Sodium Fluoride on Eroded Cervical Dentin. Operative dentistry, 46(6). doi:10.2341/20-209-L

Eyüboglu, G. B. ve Naiboǧlu, P. (2020). Clinical efficacy of different dentin desensitizers. Operative Dentistry, 45(6). doi:10.2341/19-258-C

Frechoso, S. C., Menéndez, M., Guisasola, C., Arregui, I., Tejerina, J. M. ve Sicilia, A. (2003). Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial. Journal of Clinical Periodontology, 30(4). doi:10.1034/j.1600-051X.2003.20077.x

Gaffar, A. (1999). Treating hypersensitivity with fluoride varnish. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 20(1 Suppl).

Garofalo, S. A., Sakae, L. O., Machado, A. C., Cunha, S. R., Zezell, D. M., Scaramucci, T. ve Corrêa Aranha, A. C. (2019). in vitro effect of innovative desensitizing agents on dentin tubule occlusion and erosive wear. Operative Dentistry, 44(2). doi:10.2341/17-284-L

Gluma Desensitizer Tips&Tricks Brochure, August 2022 (

Green, B. L., Green, M. L. ve McFall, W. T. (1977). Calcium Hydroxide and Potassium Nitrate as Desensitizing Agents for Hypersensitive Root Surfaces,. Journal of Periodontology, 48(10). doi:10.1902/jop.1977.48.10.667

Hodosh, M. (1974). A superior desensitizer--potassium nitrate. Journal of the American Dental Association (1939), 88(4). doi:10.14219/jada.archive.1974.0174

Holland, G. R. (1997). Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Journal of Clinical Periodontology, 24(11). doi:10.1111/j.1600-051X.1997.tb01194.x

Ishihata, H., Finger, W. J., Kanehira, M., Shimauchi, H. ve Komatsu, M. (2011). In vitro dentin permeability after application of gluma® desensitizer as aqueous solution or aqueous fumed silica dispersion. Journal of Applied Oral Science, 19(2). doi:10.1590/s1678-77572011000200011

Ishihata, H., Kanehira, M., Finger, W. J., Takahashi, H., Tomita, M. ve Sasaki, K. (2017). Effect of two desensitizing agents on dentin permeability in vitro. Journal of Applied Oral Science, 25(1). doi:10.1590/1678-77572016-0228

Jalali, Y. ve Lindh, L. (2010). A randomized prospective clinical evaluation of two desensitizing agents on cervical dentine sensitivity. A pilot study. Swedish Dental Journal, 34(2).

Johnson, G. ve Brännström, M. (1974). The sensitivity of dentin changes in relation to conditions at exposed tubule apertures. Acta Odontologica Scandinavica, 32(1). doi:10.3109/00016357409002530

Levin, M. P., Yearwood, L. L., & Carpenter, W. N. (1973). The desensitizing effect of calcium hydroxide and magnesium hydroxide on hypersensitive dentin. Oral Surgery, Oral Medicine, Oral Pathology, 35(5). doi:10.1016/0030-4220(73)90044-3

Mahesuti, A., Duan, Y. L. ing, Wang, G., Cheng, X. R. ong ve Matis, B. A. (2014). Short-term Efficacy of Agents Containing KNO3 or CPP-ACP in Treatment of Dentin Hypersensitivity. The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA), 17(1).

Malkoç, M. A. ve Sevimay, M. (2012). Evaluation of mineral content of dentin treated with desensitizing agents and neodymium yttrium-aluminium-garnet (Nd:YAG) laser. Lasers in Medical Science, 27(4). doi:10.1007/s10103-011-0954-6

Mantzourani, M. ve Sharma, D. (2013). Dentine sensitivity: Past, present and future. Journal of Dentistry, 41(SUPPL. 4). doi:10.1016/S0300-5712(13)70002-2

Markowitz, K. ve Kim, S. (1990). Hypersensitive teeth. Experimental studies of dentinal desensitizing agents. Dental clinics of North America.

McFall, W. T. (1986). A review of the active agents available for treatment of dentinal hypersensitivity. Dental Traumatology, 2(4). doi:10.1111/j.1600-9657.1986.tb00601.x

Mehta, D., Gowda, V. S., Santosh, A., Finger, W. J. ve Sasaki, K. (2014). Randomized controlled clinical trial on the efficacy of dentin desensitizing agents. Acta odontologica Scandinavica, 72(8). doi:10.3109/00016357.2014.923112

Miglani, S., Aggarwal, V. ve Ahuja, B. (2010). Dentin hypersensitivity: Recent trends in management. Journal of Conservative Dentistry, 13(4). doi:10.4103/0972-0707.73385

Moraschini, V., da Costa, L. S. ve dos Santos, G. O. (2018). Effectiveness for dentin hypersensitivity treatment of non-carious cervical lesions: a meta-analysis. Clinical Oral Investigations. doi:10.1007/s00784-017-2330-9

Nagata, T., Ishida, H., Shinohara, H., Nishikawa, S., Kasahara, S., Wakano, Y., … Troullos, E. S. (1994). Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. Journal of Clinical Periodontology, 21(3). doi:10.1111/j.1600-051X.1994.tb00307.x

Orchardson, R., & Gillam, D. G. (2006). Managing dentin hypersensitivity. Journal of the American Dental Association, 137(7). doi:10.14219/jada.archive.2006.0321

Paramesh, Y., Durgabhavani, G., Suneelkumar, C., Gonapa, P. ve Rathod, R. (2023). Comparative clinical evaluation of two different formulated in-office newer desensitizing agents (Clinpro XT and Tokuyama Shield Force Plus) in reducing dentin hypersensitivity – A randomized clinical trial. Journal of Conservative Dentistry and Endodontics, 26(6). doi:10.4103/jcde.jcde_73_23

Pashley, D. H. (1986). Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. Journal of Endodontics, 12(10). doi:10.1016/S0099-2399(86)80201-1

Poulsen, S., Errboe, M., Lescay Mevil, Y. ve Glenny, A.-M. (2006). Potassium containing toothpastes for dentine hypersensitivity. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd001476.pub2

Qin, C., Xu, J., & Zhang, Y. (2006). Spectroscopic investigation of the function of aqueous 2- hydroxyethylmethacrylate/glutaraldehyde solution as a dentin desensitizer. European Journal of Oral Sciences, 114(4). doi:10.1111/j.1600-0722.2006.00382.x

Remin Pro- Voco Dental Brochure (

Santiago, S. L., Pereira, J. C. ve Martineli, A. C. B. F. (2006). Effect of commercially available and experimental potassium oxalate-based dentin desensitizing agents in dentin permeability: Influence of time and filtration system. Brazilian Dental Journal, 17(4). doi:10.1590/s0103-64402006000400007

Sauro, S., Watson, T. F. ve Thompson, I. (2011). Ultramorphology and dentine permeability changes induced by prophylactic procedures on exposed dentinal tubules in middle dentine. Medicina Oral, Patologia Oral y Cirugia Bucal, 16(7). doi:10.4317/medoral.17397

Sowinski, J. A., Battista, G. W., Petrone, M. E., Chaknis, P., Zhang, Y. P., DeVizio, W., … Proskin, H. M. (2000). A new desensitizing dentifrice--an 8-week clinical investigation. Compendium of continuing education in dentistry. (Jamesburg, N.J. : 1995). Supplement, (27).

Tarbet, W. J., Silverman, G., Fratarcangelo, P. A. ve Kanapka, J. A. (1982). Home treatment for dentinal hypersensitivity: a comparative study. Journal of the American Dental Association (1939), 105(2). doi:10.14219/jada.archive.1982.0092

Tarbet, Willard J, Silverman, G., Stolman, J. M. ve Fratarcangelo, P. A. (1980). Clinical Evaluation of a New Treatment for Dentinal Hypersensitivity. Journal of Periodontology, 51(9). doi:10.1902/jop.1980.51.9.535

Thanatvarakorn, O., Nakashima, S., Sadr, A., Prasansuttiporn, T., Thitthaweerat, S. ve Tagami, J. (2013). Effect of a calcium-phosphate based desensitizer on dentin surface characteristics. Dental Materials Journal, 32(4). doi:10.4012/dmj.2013-073

Teethmate Desensitizer Brochure (

Tokuyama Shield Force Plus, Technical Report. Retrieved online November 10, 2019 (

Torres, C. R. G., Da Silva, T. M., Da Fonseca, B. M., Sales, A. L. L. S., Holleben, P., Di Nicolo, R. ve Borges, A. B. (2014). The effect of three desensitizing agents on dentin hypersensitivity: A randomized, split-mouth clinical trial. Operative Dentistry, 39(5). doi:10.2341/13-057

Usai, P., Campanella, V., Sotgiu, G., Spano, G., Pinna, R., Eramo, S., … Milia, E. (2019). Effectiveness of calcium phosphate desensitising agents in dental hypersensitivity over 24 weeks of clinical evaluation. Nanomaterials, 9(12). doi:10.3390/nano9121748

West, N. X., Seong, J. ve Davies, M. (2015). Management of dentine hypersensitivity: Efficacy of professionally and self-administered agents. Journal of Clinical Periodontology, 42(S16). doi:10.1111/jcpe.12336



How to Cite

KURŞUN, S. (2024). Current Desensitizing Agents for the Treatment of Dentin Hypersensitivity. International Journal of Health and Applied Science, 2(2), 57–72.